Format

Send to:

Choose Destination
See comment in PubMed Commons below
World J Gastroenterol. 2011 Apr 28;17(16):2131-6. doi: 10.3748/wjg.v17.i16.2131.

Ku80 gene G-1401T promoter polymorphism and risk of gastric cancer.

Author information

  • 1Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.

Abstract

AIM:

To evaluate the possible relationship between the Ku80 gene polymorphism and the risk of gastric cancer in China.

METHODS:

In this hospital-based case-control study of gastric cancer in Jiangsu Province, China, we investigated the association of the Ku80 G-1401T (rs828907) polymorphism with gastric cancer risk. A total of 241 patients with gastric cancer and 273 age- and sex-matched control subjects were genotyped and analyzed by polymerase chain reaction-restriction fragment length polymorphism.

RESULTS:

The frequencies of genotypes GG, GT and TT were 65.6%, 22.8% and 11.6% in gastric cancer cases, respectively, and 75.8%, 17.6% and 6.6% in controls, respectively. There were significant differences between gastric cancer and control groups in the distribution of their genotypes (P = 0.03) and allelic frequencies (P = 0.002) in the Ku80 promoter G-1401T polymorphism.

CONCLUSION:

The T allele of Ku80 G-1401T may be associated with the development of gastric cancer.

KEYWORDS:

Carcinogenesis; Gastric cancer; Ku80; Polymorphism; Promoter

PMID:
21547134
[PubMed - indexed for MEDLINE]
PMCID:
PMC3084400
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Baishideng Publishing Group Inc. Icon for PubMed Central
    Loading ...
    Write to the Help Desk