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Nature. 1990 Feb 15;343(6259):617-22.

Cloning of the T gene required in mesoderm formation in the mouse.

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  • 1Laboratory of Molecular Embryology, National Institute for Medical Research, London, UK.


The murine developmental mutation T identifies an essential gene in mesoderm formation. Embryos lacking normal gene activity fail to form the notochord, the entire posterior region and the allantois, and die at about 10 days of gestation. We have isolated the T gene using a combination of molecular and genetic techniques, thus making molecular tools available to study processes underlying mesoderm formation in the mouse.

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