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Blood. 2011 Aug 4;118(5):1305-15. doi: 10.1182/blood-2011-01-331462. Epub 2011 May 4.

Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c⁺ B-cell population is important for the development of autoimmunity.

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  • 1Howard Hughes Medical Institute and Department of Immunology, National Jewish Health and University of Colorado Health Sciences Center, Denver, CO 80206, USA. rubtsova@njhealth.org

Abstract

Females are more susceptible than males to many autoimmune diseases. The processes causing this phenomenon are incompletely understood. Here, we demonstrate that aged female mice acquire a previously uncharacterized population of B cells that we call age-associated B cells (ABCs) and that these cells express integrin α(X) chain (CD11c). This unexpected population also appears in young lupus-prone mice. On stimulation, CD11c(+) B cells, both from autoimmune-prone and healthy strains of mice, secrete autoantibodies, and depletion of these cells in vivo leads to reduction of autoreactive antibodies, suggesting that the cells might have a direct role in the development of autoimmunity. We have explored factors that contribute to appearance of ABCs and demonstrated that signaling through Toll-like receptor 7 is crucial for development of this B cell population. We were able to detect a similar population of B cells in the peripheral blood of some elderly women with autoimmune disease, suggesting that there may be parallels between the creation of ABC-like cells between mice and humans.

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PMID:
21543762
[PubMed - indexed for MEDLINE]
PMCID:
PMC3152497
Free PMC Article
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