Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Curr Opin Genet Dev. 2011 Aug;21(4):474-83. doi: 10.1016/j.gde.2011.03.007. Epub 2011 May 3.

The cancerous translation apparatus.

Author information

  • 1School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158-3110, USA.

Abstract

Deregulations in translational control are critical features of cancer initiation and progression. Activation of key oncogenic pathways promotes rapid and dramatic translational reprogramming, not simply by increasing overall protein synthesis, but also by modulating specific mRNA networks that promote cellular transformation. Additionally, ribosomopathies caused by mutations in ribosome components alter translational regulation leading to specific pathological features, including cancer susceptibility. Exciting advances in our understanding of translational control in cancer have illuminated a striking specificity innate to the translational apparatus. Characterizing this specificity will provide novel insights into how cells normally utilize translational control to modulate gene expression, how it is deregulated in cancer, and how these processes can be targeted to develop new cancer therapies.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
21543223
[PubMed - indexed for MEDLINE]
PMCID:
PMC3481834
Free PMC Article

Images from this publication.See all images (2)Free text

Figure 1
Figure 2
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk