Is Raf1 a nexus for cardiac hypertrophic signaling in human disease?

J Mol Cell Cardiol. 2011 Jul;51(1):1-3. doi: 10.1016/j.yjmcc.2011.04.004. Epub 2011 Apr 22.
No abstract available

Publication types

  • Comment
  • Editorial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cardiomegaly / metabolism*
  • Cardiomyopathy, Hypertrophic / genetics
  • Cardiomyopathy, Hypertrophic / metabolism*
  • Humans
  • LEOPARD Syndrome / genetics
  • LEOPARD Syndrome / metabolism
  • LEOPARD Syndrome / pathology
  • MAP Kinase Kinase 1 / metabolism
  • MAP Kinase Kinase 3 / metabolism
  • Mice
  • Mitogen-Activated Protein Kinase 1 / metabolism
  • Mitogen-Activated Protein Kinase 3 / metabolism
  • Mutation
  • Noonan Syndrome / genetics
  • Noonan Syndrome / metabolism
  • Noonan Syndrome / pathology
  • Protein Tyrosine Phosphatase, Non-Receptor Type 11 / genetics
  • Proto-Oncogene Proteins c-raf / chemistry
  • Proto-Oncogene Proteins c-raf / genetics*
  • Proto-Oncogene Proteins c-raf / metabolism*
  • Signal Transduction

Substances

  • Proto-Oncogene Proteins c-raf
  • MAPK1 protein, human
  • Mitogen-Activated Protein Kinase 1
  • Mitogen-Activated Protein Kinase 3
  • MAP Kinase Kinase 1
  • MAP Kinase Kinase 3
  • PTPN11 protein, human
  • Protein Tyrosine Phosphatase, Non-Receptor Type 11