Biochem Biophys Res Commun. 2011 May 20;408(4):701-6. doi: 10.1016/j.bbrc.2011.04.095. Epub 2011 Apr 24.

New microbial mannan catabolic pathway that involves a novel mannosylglucose phosphorylase.

Senoura T, Ito S, Taguchi H, Higa M, Hamada S, Matsui H, Ozawa T, Jin S, Watanabe J, Wasaki J, Ito S.

Source

Creative Research Initiative 'Sousei', Hokkaido University, N-21 W-10 Kita-ku, Sapporo, Japan.

Abstract

The consecutive genes BF0771-BF0774 in the genome of Bacteroides fragilis NCTC 9343 were found to constitute an operon. The functional analysis of BF0772 showed that the gene encoded a novel enzyme, mannosylglucose phosphorylase that catalyzes the reaction, 4-O-β-d-mannopyranosyl-d-glucose+Pi→mannose-1-phosphate+glucose. Here we propose a new mannan catabolic pathway in the anaerobe, which involves 1,4-β-mannanase (BF0771), a mannobiose and/or sugar transporter (BF0773), mannobiose 2-epimerase (BF0774), and mannosylglucose phosphorylase (BF0772), finally progressing to glycolysis. This pathway is distributed in microbes such as Bacteroides, Parabacteroides, Flavobacterium, and Cellvibrio.

PMID:: 21539815; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

GLUCOSE - HSDB

Supplemental Content

Save items

Related citations in PubMed

Metabolic mechanism of mannan in a ruminal bacterium, Ruminococcus albus, involving two mannoside phosphorylases and cellobiose 2-epimerase: discovery of a new carbohydrate phosphorylase, β-1,4-mannooligosaccharide phosphorylase. [J Biol Chem. 2012]
Metabolic mechanism of mannan in a ruminal bacterium, Ruminococcus albus, involving two mannoside phosphorylases and cellobiose 2-epimerase: discovery of a new carbohydrate phosphorylase, β-1,4-mannooligosaccharide phosphorylase.
Kawahara R, Saburi W, Odaka R, Taguchi H, Ito S, Mori H, Matsui H. J Biol Chem. 2012 Dec 7; 287(50):42389-99. Epub 2012 Oct 23.
Identification of the cellobiose 2-epimerase gene in the genome of Bacteroides fragilis NCTC 9343. [Biosci Biotechnol Biochem. 2009]
Identification of the cellobiose 2-epimerase gene in the genome of Bacteroides fragilis NCTC 9343.
Senoura T, Taguchi H, Ito S, Hamada S, Matsui H, Fukiya S, Yokota A, Watanabe J, Wasaki J, Ito S. Biosci Biotechnol Biochem. 2009 Feb; 73(2):400-6. Epub 2009 Feb 7.
Sialic acid (N-acetyl neuraminic acid) utilization by Bacteroides fragilis requires a novel N-acetyl mannosamine epimerase. [J Bacteriol. 2009]
Sialic acid (N-acetyl neuraminic acid) utilization by Bacteroides fragilis requires a novel N-acetyl mannosamine epimerase.
Brigham C, Caughlan R, Gallegos R, Dallas MB, Godoy VG, Malamy MH. J Bacteriol. 2009 Jun; 191(11):3629-38. Epub 2009 Mar 20.
Characterization of three beta-galactoside phosphorylases from Clostridium phytofermentans: discovery of d-galactosyl-beta1->4-l-rhamnose phosphorylase. [J Biol Chem. 2009]
Characterization of three beta-galactoside phosphorylases from Clostridium phytofermentans: discovery of d-galactosyl-beta1->4-l-rhamnose phosphorylase.
Nakajima M, Nishimoto M, Kitaoka M. J Biol Chem. 2009 Jul 17; 284(29):19220-7. Epub 2009 Jun 2.
Review Regulation of E. coli glycogen phosphorylase activity by HPr. [J Mol Microbiol Biotechnol. 2001]
Review Regulation of E. coli glycogen phosphorylase activity by HPr.
Seok YJ, Koo BM, Sondej M, Peterkofsky A. J Mol Microbiol Biotechnol. 2001 Jul; 3(3):385-93.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (GeneRIF)
Gene records that have the current articles as Reference into Function citations (GeneRIFs). NLM staff reviewing the literature while indexing MEDLINE add GeneRIFs manually.
MedGen
Related information in MedGen
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Protein Clusters
Clusters of related proteins from the Protein Clusters database that cite the current articles. Sources of references in Protein Clusters include the associated Gene and Conserved Domain records as well as NCBI added citations.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.

Recent activity

Clear Turn Off Turn On

New microbial mannan catabolic pathway that involves a novel mannosylglucose pho...
New microbial mannan catabolic pathway that involves a novel mannosylglucose phosphorylase.
Biochem Biophys Res Commun. 2011 May 20 ;408(4):701-6. doi: 10.1016/j.bbrc.2011.04.095. Epub 2011 Apr 24 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

New microbial mannan catabolic pathway that involves a novel mannosylglucose phosphorylase.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information