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J Interv Cardiol. 2011 Oct;24(5):416-23. doi: 10.1111/j.1540-8183.2011.00650.x. Epub 2011 May 3.

Drug-eluting stents during ST-segment elevation acute myocardial infarction: a critical analysis.

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  • 1Irmandade da Santa Casa de Misericórdia de Marília, Av. Vicente Ferreira 828, Marília, São Paulo, Brazil.


Primary percutaneous coronary intervention is the preferred reperfusion therapy for ST-segment elevation acute myocardial infarction patients within 12 hours of symptom-onset. Routine stent implantation during the procedure significantly reduces the rate of target vessel revascularization, although restenosis still represents a current limitation of the technique. Drug-eluting stents were developed to treat and prevent coronary restenosis. Randomized trials, meta-analysis, and registries proved their efficacy and safety in different clinical situations, including acute myocardial infarction. However, the increased risk of late stent thrombosis associated with drug-eluting stents during primary percutaneous coronary interventions encourages a careful analysis to identify which patients most benefit from them, as well as those where a prolonged dual antiplatelet therapy does not represent a limiting factor.

©2011, Wiley Periodicals, Inc.

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