Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Stem Cell Rev. 2012 Mar;8(1):1-15. doi: 10.1007/s12015-011-9261-7.

LIF-dependent signaling: new pieces in the Lego.

Author information

  • 1Univ. de Bordeaux, CIRID, UMR5164, F-33000, Bordeaux, France.

Abstract

LIF, a member of the IL6 family of cytokine, displays pleiotropic effects on various cell types and organs. Its critical role in stem cell models (e.g.: murine ES, human mesenchymal cells) and its essential non redundant function during the implantation process of embryos, in eutherian mammals, put this cytokine at the core of many studies aiming to understand its mechanisms of action, which could benefit to medical applications. In addition, its conservation upon evolution raised the challenging question concerning the function of LIF in species in which there is no implantation. We present the recent knowledge about the established and potential functions of LIF in different stem cell models, (embryonic, hematopoietic, mesenchymal, muscle, neural stem cells and iPSC). We will also discuss EVO-DEVO aspects of this multifaceted cytokine.

PMID:
21537995
[PubMed - indexed for MEDLINE]
PMCID:
PMC3285761
Free PMC Article

Images from this publication.See all images (1)Free text

Fig. 1
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Springer Icon for PubMed Central
    Loading ...
    Write to the Help Desk