Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Struct Funct Genomics. 2011 Jul;12(2):109-17. doi: 10.1007/s10969-011-9110-6. Epub 2011 May 3.

Beyond structural genomics: computational approaches for the identification of ligand binding sites in protein structures.

Author information

  • 1Department of Structural and Chemical Biology, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA.

Abstract

Structural genomics projects have revealed structures for a large number of proteins of unknown function. Understanding the interactions between these proteins and their ligands would provide an initial step in their functional characterization. Binding site identification methods are a fast and cost-effective way to facilitate the characterization of functionally important protein regions. In this review we describe our recently developed methods for binding site identification in the context of existing methods. The advantage of energy-based approaches is emphasized, since they provide flexibility in the identification and characterization of different types of binding sites.

PMID:
21537951
[PubMed - indexed for MEDLINE]
PMCID:
PMC3127736
Free PMC Article

Images from this publication.See all images (4)Free text

Fig. 1
Fig. 2
Fig. 3
Fig. 4
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer Icon for PubMed Central
    Loading ...
    Write to the Help Desk