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Hum Immunol. 2011 Aug;72(8):667-70. doi: 10.1016/j.humimm.2011.03.026. Epub 2011 Apr 15.

Genetic variation at immunoglobulin kappa locus is associated with hepatitis C-treatment-induced viral clearance in African Americans.

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  • 1Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.


Host genetic factors, especially genes of the immune system, are thought to contribute to the racial differences in response rates to therapy for hepatitis C virus (HCV) infection. The aim of the present investigation was to determine whether immunoglobulin gamma heavy chain marker (GM) and kappa light chain marker (KM) -were associated with sustained viral response (SVR) in patients treated with peginterferon-α-2a and ribavirin. DNA samples from 319 subjects with genotype-1 HCV infections were allotyped for alleles at four GM loci: GM3/GM17, GM23+/GM23-, GM5/GM21, GM6+/GM6- and the KM locus: KM1/KM3, using molecular methods. Noncarriage of KM1 allele, i.e., KM3 homozygosity, was associated with higher SVR in African Americans (odds ratio = 2.50, 95% confidence interval = 1.12-5.60). Consistent with this finding, the HCV RNA level in KM1 noncarriers was significantly (p = 0.013) lower than in carriers of this allele. Thus, the KM3 allele may be a marker for higher SVR in African Americans.

Copyright © 2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

[PubMed - indexed for MEDLINE]
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