Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Acta Paediatr. 2011 Dec;100(12):e280-2. doi: 10.1111/j.1651-2227.2011.02338.x. Epub 2011 Jun 29.

Clinical and metabolic findings in a 6-year-old boy with a Leydig cell tumour.

Author information

  • 1Department of Pediatrics, Johannes Gutenberg University Medical School, Mainz, Germany.



To analyse the urinary steroid metabolome in a boy who had true precocious puberty after a Leydig cell tumour.


Case report and detailed description of clinical and metabolic findings in a 7-year-old-boy with a Leydig cell tumour.


  Before surgery, the urinary steroid metabolome showed an activation of an alternative route to gonadal androgens independent of dehydroepiandrosterone (DHEA). After surgery, the boy entered true precocious puberty. Under leuprolide acetate treatment, clinical and laboratory findings normalized.


Central precocious puberty after precocious pseudopuberty may be more common than expected and should be considered in children with persistent or recurrent symptoms after initial treatment of precocious pseudopuberty. Patients with a Leydig cell tumour seem to reactivate the so-called 'back door pathway' of androgen production, which is independent of the classical route via DHEA.

© 2011 The Author(s)/Acta Paediatrica © 2011 Foundation Acta Paediatrica.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Blackwell Publishing
    Loading ...
    Write to the Help Desk