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J Med Chem. 2011 Jun 9;54(11):3866-74. doi: 10.1021/jm2001579. Epub 2011 May 13.

Highly potent activity of (1R,2R,6S)-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol in animal models of Parkinson's disease.

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  • 1Russian Academy of Sciences, Novosibirsk, Russian Federation.

Abstract

(1R,2R,6S)-3-Methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol 1 possesses potent antiparkinsonian activity in both MPTP and haloperidol animal models. The use of compound 1 resulted in nearly full recovery of the locomotor and exploratory activities and was as effective as the comparator agent (levodopa). All eight stereoisomers of compound 1 have been synthesized and the influence of the absolute configuration on the antiparkinsonian activity of compound 1 was shown.

PMID:
21534547
[PubMed - indexed for MEDLINE]
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