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Cell Metab. 2011 May 4;13(5):493-4. doi: 10.1016/j.cmet.2011.04.006.

A potential link between dorsomedial hypothalamic nucleus NPY and energy balance.

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  • 1Department of Biology, Neurobiology and Behavior Program, Georgia State University, Atlanta, 30302-4010, USA.


The function of dorsomedial hypothalamic neuropeptide Y (NPY) in energy balance has largely been restricted to lactation-induced hyperphagia. In this issue, Chao et al. (2011) expand this role to include inhibition of both brown fat thermogenesis and conversion of white-to-brown adipocytes in a white fat depot, resulting in reduced energy expenditure.

Copyright © 2011 Elsevier Inc. All rights reserved.

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