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Arch Phys Med Rehabil. 2011 May;92(5):749-55. doi: 10.1016/j.apmr.2010.12.020.

Pragmatic lifestyle intervention in patients recovering from colon cancer: a randomized controlled pilot study.

Author information

  • 1eNIHR Cardiovascular Biomedical Research Unit, Sheffield Foundation Trust National Health Service Trust, Sheffield, United Kingdom.

Abstract

OBJECTIVE:

To investigate the feasibility of a pragmatic lifestyle intervention in patients who had recently completed surgery and chemotherapy for colon cancer and to obtain preliminary data of its impact on important health outcomes.

DESIGN:

A prospective, randomized, controlled pilot trial.

SETTING:

University rehabilitation facility.

PARTICIPANTS:

Eighteen (N=18) colon cancer survivors (mean age=69y; range, 52-80y), Dukes stage A to C.

INTERVENTIONS:

Participants were randomized 6 to 24 months postoperatively to either a 12-week program of combined exercise and dietary advice or standard treatment.

MAIN OUTCOME MEASURES:

Exercise and dietary behavior, fatigue, health-related quality of life (QOL), aerobic exercise tolerance, functional capacity, muscle strength, and anthropometery were assessed at baseline and immediately after the intervention.

RESULTS:

Adherences to supervised and independent exercise during the intervention were 90% and 94%, respectively, and there was low attrition (6%). The lifestyle intervention elicited improvements in exercise behavior (P=.068), fatigue (P=.005), aerobic exercise tolerance (P=.010), chair sit-to-stand performance (P=.003), and waist-to-hip ratio (P=.002). A positive change in dietary fiber intake (P=.044) was also observed in the intervention group. No change in QOL was observed (P=.795).

CONCLUSIONS:

These preliminary results suggest that a pragmatic lifestyle intervention implemented 6 to 24 months after primary treatment for colon cancer was feasible. We observed a significant impact on dietary behavior, fatigue, aerobic exercise tolerance, functional capacity, and waist-to-hip ratio. These findings need to be confirmed with a larger-scale definitive randomized controlled trial.

Copyright © 2011 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

PMID:
21530722
[PubMed - indexed for MEDLINE]
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