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Curr Opin Genet Dev. 2011 Aug;21(4):511-7. doi: 10.1016/j.gde.2011.04.003. Epub 2011 Apr 29.

MicroRNAs and developmental timing.

Author information

  • 1UMass Medical School, Molecular Medicine, 373 Plantation St, Worcester, MA 01605, USA. victor.ambros@umassmed.edu

Abstract

MicroRNAs regulate temporal transitions in gene expression associated with cell fate progression and differentiation throughout animal development. Genetic analysis of developmental timing in the nematode Caenorhabditis elegans identified two evolutionarily conserved microRNAs, lin-4/mir-125 and let-7, that regulate cell fate progression and differentiation in C. elegans cell lineages. MicroRNAs perform analogous developmental timing functions in other animals, including mammals. By regulating cell fate choices and transitions between pluripotency and differentiation, microRNAs help to orchestrate developmental events throughout the developing animal, and to play tissue homeostasis roles important for disease, including cancer.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
21530229
[PubMed - indexed for MEDLINE]
PMCID:
PMC3149784
Free PMC Article
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