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J Am Chem Soc. 2011 May 25;133(20):7656-9. doi: 10.1021/ja201031g. Epub 2011 Apr 29.

Selective biomolecular nanoarrays for parallel single-molecule investigations.

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  • 1Department of Applied Physics & Applied Mathematics, Columbia University, New York, New York 10027, USA. mp2766@columbia.edu

Abstract

The ability to direct the self-assembly of biomolecules on surfaces with true nanoscale control is key for the creation of functional substrates. Herein we report the fabrication of nanoscale biomolecular arrays via selective self-assembly on nanopatterned surfaces and minimized nonspecific adsorption. We demonstrate that the platform developed allows for the simultaneous screening of specific protein-DNA binding events at the single-molecule level. The strategy presented here is generally applicable and enables high-throughput monitoring of biological activity in real time and with single-molecule resolution.

PMID:
21528859
[PubMed - indexed for MEDLINE]
PMCID:
PMC3108261
Free PMC Article
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