Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Ethnopharmacol. 2011 Jun 1;135(3):792-6. doi: 10.1016/j.jep.2011.04.025. Epub 2011 Apr 16.

Wound healing and antimicrobial potential of Carissa spinarum Linn. in albino mice.

Author information

  • 1School of Pharmaceutical Sciences, Shobhit University, Meerut, UP-250110, India.

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE:

Carissa spinarum Linn. (Apocynaceae), popularly known as Jungle karunda, has been traditionally used as wound healing agent.

AIM OF THE STUDY:

To investigate in vivo wound healing and antimicrobial properties of methanolic extract of Carissa spinarum.

MATERIALS AND METHODS:

The effect of methanolic extract of Carissa spinarum root extracted by cold maceration was evaluated on burn wound model in mice. The wound healing activity of 1% and 2.5% (w/w) extract was assessed by the rate of wound contraction, period of epithelization and hydroxyproline content. Histological study of the granulation tissue was carried out to know the extent of collagen formation in the wound tissue. The antimicrobial activity of extract was also studied against the bacterial and fungal strain using agar dilution method.

RESULTS:

The results showed that Carissa spinarum root extract has significant wound healing activity as evident from the rate of wound contraction and epithelization. Hydroxyproline expressions and histological parameters were also well correlated with the healing pattern observed. Methanolic extract also exhibited significant antimicrobial activity against all the tested microorganisms.

CONCLUSIONS:

The present study provides a scientific rationale for the traditional use of Carissa spinarum in the management of wounds.

Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

PMID:
21527332
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk