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Fly (Austin). 2011 Jul-Sep;5(3):242-6. Epub 2011 Jul 1.

Morphogen gradient formation and action: insights from studying Bicoid protein degradation.

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  • 1Division of Biomedical Informatics, Cincinnati Children's Research Foundation, Cincinnati, OH, USA.

Abstract

In a recent publication, we identified a novel F-box protein, encoded by fates-shifted (fsd), that plays a role in targeting Bcd for ubiquitination and degradation. Our analysis of mutant Drosophila embryos suggests that Bcd protein degradation is important for proper gradient formation and developmental fate specification. Here we describe further experiments that lead to an estimate of Bcd half-life, < 15 min, in embryos during the time of gradient formation. We use our findings to evaluate different models of Bcd gradient formation. With this new estimate, we simulate the Bcd gradient formation process in our own biologically realistic 2-D model. Finally, we discuss the role of Bcd-encoded positional information in controlling the positioning and precision of developmental decisions.

PMID:
21525787
[PubMed - indexed for MEDLINE]
PMCID:
PMC3225767
Free PMC Article
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