Cracking the combinatorial semaphorin code

Brett Berke; Haig Keshishian

doi:10.1016/j.neuron.2011.04.010

Cracking the combinatorial semaphorin code

Neuron. 2011 Apr 28;70(2):175-7. doi: 10.1016/j.neuron.2011.04.010.

Authors

Brett Berke¹, Haig Keshishian

Affiliation

¹ Molecular, Cellular, and Developmental Biology Department, Yale University, POB 208103, New Haven, CT 06520-8103, USA.

PMID: 21521607
DOI: 10.1016/j.neuron.2011.04.010

Abstract

In this issue of Neuron, Wu et al. describe a combinatorial code of repulsive Sema-2a and attractive Sema-2b signaling that mediates mechanosensory axonal guidance, fasciculation, and synaptic target selection within the CNS of Drosophila. Their work exemplifies how a detailed, multilevel molecular-genetic analysis (from molecules to behavior) provides fundamental insights into neural circuit development.

Publication types

Comment

Grants and funding

R01 NS031651/NS/NINDS NIH HHS/United States