An unusual case of purely osteoblastic metastasis in the spine from adenocarcinoma of the pancreas was reported. Severe low back pain with osteoblastic lesions pictured in a lumbar X-ray study were the initial manifestations. A percutaneous transpedicular vertebral bodies biopsy was performed and showed a metastatic adenocarcinoma. This clinical presentation is unusual and the diagnosis of pancreatic carcinoma should be considered when radiographs or bone scans show osteoblastic bone lesions.