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Ann Neurol. 2011 Apr;69(4):655-63. doi: 10.1002/ana.22271. Epub 2010 Nov 29.

Plasma epidermal growth factor levels predict cognitive decline in Parkinson disease.

Author information

  • 1Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

Abstract

OBJECTIVE:

Most people with Parkinson disease (PD) eventually develop cognitive impairment (CI). However, neither the timing of onset nor the severity of cognitive symptoms can be accurately predicted. We sought plasma-based biomarkers for CI in PD.

METHODS:

A discovery cohort of 70 PD patients was recruited. Cognitive status was evaluated with the Mattis Dementia Rating Scale-2 (DRS) at baseline and on annual follow-up visits, and baseline plasma levels of 102 proteins were determined with a bead-based immunoassay. Using linear regression, we identified biomarkers of CI in PD, that is, proteins whose levels correlated with cognitive performance at baseline and/or cognitive decline at follow-up. We then replicated the association between cognitive performance and levels of the top biomarker, using a different technical platform, with a separate cohort of 113 PD patients.

RESULTS:

Eleven proteins exhibited plasma levels correlating with baseline cognitive performance in the discovery cohort. The best candidate was epidermal growth factor (EGF, p < 0.001); many of the other 10 analytes covaried with EGF across samples. Low levels of EGF not only correlated with poor cognitive test scores at baseline, but also predicted an 8-fold greater risk of cognitive decline to dementia-range DRS scores at follow-up for those with intact baseline cognition. A weaker, but still significant, relationship between plasma EGF levels and cognitive performance was found in an independent replication cohort of 113 PD patients.

INTERPRETATION:

Our data suggest that plasma EGF may be a biomarker for progression to CI in PD.

Copyright © 2010 American Neurological Association.

Comment in

  • Growth factors in Parkinson's disease. [Biomark Med. 2011]
PMID:
21520231
[PubMed - indexed for MEDLINE]
PMCID:
PMC3155276
Free PMC Article

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