Metabolic imbalance associated with methylation dysregulation and oxidative damage in children with autism

J Autism Dev Disord. 2012 Mar;42(3):367-77. doi: 10.1007/s10803-011-1260-7.

Abstract

Oxidative stress and abnormal DNA methylation have been implicated in the pathophysiology of autism. We investigated the dynamics of an integrated metabolic pathway essential for cellular antioxidant and methylation capacity in 68 children with autism, 54 age-matched control children and 40 unaffected siblings. The metabolic profile of unaffected siblings differed significantly from case siblings but not from controls. Oxidative protein/DNA damage and DNA hypomethylation (epigenetic alteration) were found in autistic children but not paired siblings or controls. These data indicate that the deficit in antioxidant and methylation capacity is specific for autism and may promote cellular damage and altered epigenetic gene expression. Further, these results suggest a plausible mechanism by which pro-oxidant environmental stressors may modulate genetic predisposition to autism.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Autistic Disorder / metabolism*
  • Case-Control Studies
  • Child
  • Child, Preschool
  • DNA Methylation
  • Female
  • Glutathione / metabolism
  • Humans
  • Male
  • Oxidative Stress / physiology*
  • Reactive Oxygen Species / metabolism*

Substances

  • Reactive Oxygen Species
  • Glutathione