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Cell Signal. 2011 Sep;23(9):1424-32. doi: 10.1016/j.cellsig.2011.04.004. Epub 2011 Apr 14.

Homomeric and heteromeric complexes among TGF-β and BMP receptors and their roles in signaling.

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  • 1Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.

Abstract

Transforming growth factor-β (TGF-β) ligands and bone morphogenetic proteins (BMPs) play myriad roles in many biological processes and diseases. Their pluripotent activities are subject to multiple levels of regulation, including receptor oligomerization, endocytosis, association with co-receptors, cellular scaffolds or membrane domains, as well as transcriptional control. In this review, we focus on TGF-β and BMP receptor homomeric and heteromeric complex formation and their modulation by ligand binding, which regulate signaling on a near-immediate timescale. We discuss the current structural, biochemical and biophysical evidence for the oligomerization of these receptors, and the potential roles of distinct oligomeric interactions in signaling.

Copyright © 2011 Elsevier Inc. All rights reserved.

PMID:
21515362
[PubMed - indexed for MEDLINE]

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