Send to:

Choose Destination
See comment in PubMed Commons below
Biol Psychiatry. 2011 Oct 1;70(7):696-8. doi: 10.1016/j.biopsych.2011.02.034. Epub 2011 Apr 22.

Common sequence variants in the major histocompatibility complex region associate with cerebral ventricular size in schizophrenia.

Author information

  • 1Institute of Clinical Medicine, Department of Biostatistics, University of Oslo, Oslo, Norway.



Because of evidence from genetic linkage and genome-wide association studies, as well as suggested involvement of infection, the major histocompatibility complex (MHC) region on chromosome 6p21.3-22.1 has been implicated in the development of schizophrenia.


Here, we investigated how gene variants across the MHC region are associated with brain structure in a large ethnically homogenous sample (n = 420), including patients with schizophrenia spectrum disorders and other severe mental illness and healthy control subjects.


We demonstrate highly significant associations between common gene markers in the MHC region and cerebral ventricular volume specifically in schizophrenia spectrum patients (uncorrected p values between 1.16 × 10⁻⁴ and 2.00 × 10⁻⁷). One single nucleotide polymorphism, rs2596532, survives Bonferroni correction for multiple testing across all single nucleotide polymorphisms and brain structure measures (adjusted p value 5.59 × 10⁻⁴).


The results indicate that MHC variants are implicated in characteristic brain abnormalities of schizophrenia.

Copyright © 2011 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk