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Biol Psychiatry. 2011 Oct 1;70(7):696-8. doi: 10.1016/j.biopsych.2011.02.034. Epub 2011 Apr 22.

Common sequence variants in the major histocompatibility complex region associate with cerebral ventricular size in schizophrenia.

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  • 1Institute of Clinical Medicine, Department of Biostatistics, University of Oslo, Oslo, Norway. Ingrid.Agartz@medisin.uio.no

Abstract

BACKGROUND:

Because of evidence from genetic linkage and genome-wide association studies, as well as suggested involvement of infection, the major histocompatibility complex (MHC) region on chromosome 6p21.3-22.1 has been implicated in the development of schizophrenia.

METHODS:

Here, we investigated how gene variants across the MHC region are associated with brain structure in a large ethnically homogenous sample (n = 420), including patients with schizophrenia spectrum disorders and other severe mental illness and healthy control subjects.

RESULTS:

We demonstrate highly significant associations between common gene markers in the MHC region and cerebral ventricular volume specifically in schizophrenia spectrum patients (uncorrected p values between 1.16 × 10⁻⁴ and 2.00 × 10⁻⁷). One single nucleotide polymorphism, rs2596532, survives Bonferroni correction for multiple testing across all single nucleotide polymorphisms and brain structure measures (adjusted p value 5.59 × 10⁻⁴).

CONCLUSIONS:

The results indicate that MHC variants are implicated in characteristic brain abnormalities of schizophrenia.

Copyright © 2011 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

PMID:
21514568
[PubMed - indexed for MEDLINE]
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