Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Curr Opin Struct Biol. 2011 Jun;21(3):419-25. doi: 10.1016/j.sbi.2011.03.012. Epub 2011 Apr 21.

Unstructural biology coming of age.

Author information

  • Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary. tompa@enzim.hu

Abstract

It is now generally accepted that many proteins or protein domains (intrinsically disordered proteins, IDPs) lack a well-defined tertiary structure under functional conditions. Due to recent concerted activity, a critical transition in this field is gaining momentum, in which qualitative observations are turned into quantitative structural models of IDPs. Here, it is suggested that the transition is set up by the synergy of: (i) more advanced bioinformatic tools for the prediction of disorder and function of IDPs, (ii) ensemble description of their structure and dynamics in both free and bound states, down to the single molecule level, (iii) advent of in-cell approaches for characterizing their structure and function in vivo, and (iv) generation of small-molecule inhibitors both against their binding partners and IDPs themselves. In all, we suggest that due to steady advance in these areas, the field of 'unstructural' biology is rapidly maturing to a state where it can provide quantitative models of proteins functioning without well-defined three-dimensional structures.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
21514142
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk