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Autoimmun Rev. 2011 Jul;10(9):536-43. doi: 10.1016/j.autrev.2011.04.004. Epub 2011 Apr 13.

Dysregulated neutrophil--endothelial interaction in antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides: implications for pathogenesis and disease intervention.

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  • 1Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Abstract

The interplay between neutrophils and endothelial cells allows ANCA to become pathogenic and results in uncontrolled inflammation in the vessel wall. This review presents an overall view on neutrophil-endothelial interaction during inflammation with a focus on ANCA-associated vasculitis, and summarizes the effector mechanisms which cause vascular damage in AAV. In addition, potential elements for disease intervention based on this process are discussed.

Copyright © 2011 Elsevier B.V. All rights reserved.

PMID:
21513817
[PubMed - indexed for MEDLINE]
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