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Arch Biochem Biophys. 2011 Jun 15;510(2):93-100. doi: 10.1016/j.abb.2011.04.003. Epub 2011 Apr 14.

Regulation of ciliary motility: conserved protein kinases and phosphatases are targeted and anchored in the ciliary axoneme.

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  • 1Emory University School of Medicine, Department of Cell Biology, Atlanta, GA 30322, USA. mwirschell@gmail.com


Recent evidence has revealed that the dynein motors and highly conserved signaling proteins are localized within the ciliary 9+2 axoneme. One key mechanism for regulation of motility is phosphorylation. Here, we review diverse evidence, from multiple experimental organisms, that ciliary motility is regulated by phosphorylation/dephosphorylation of the dynein arms through kinases and phosphatases that are anchored immediately adjacent to their axonemal substrates.

Copyright © 2011 Elsevier Inc. All rights reserved.

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