Medicine. Progranulin resolves inflammation

Science. 2011 Apr 22;332(6028):427-8. doi: 10.1126/science.1205992.

Abstract

A molecule binds to a cytokine receptor and limits the cytokine from eliciting inflammatory responses by immune cells.

Publication types

  • Comment

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / metabolism
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Arthritis, Experimental / drug therapy
  • Arthritis, Experimental / immunology*
  • Arthritis, Experimental / metabolism*
  • Binding, Competitive
  • Granulins
  • Humans
  • Intercellular Signaling Peptides and Proteins / genetics
  • Intercellular Signaling Peptides and Proteins / metabolism*
  • Intercellular Signaling Peptides and Proteins / pharmacology
  • Ligands
  • Mice
  • Progranulins
  • Protein Binding
  • Protein Interaction Domains and Motifs
  • Receptors, Tumor Necrosis Factor, Type I / chemistry
  • Receptors, Tumor Necrosis Factor, Type I / metabolism*
  • Receptors, Tumor Necrosis Factor, Type II / chemistry
  • Receptors, Tumor Necrosis Factor, Type II / metabolism*
  • Recombinant Fusion Proteins / metabolism
  • Recombinant Fusion Proteins / pharmacology
  • Signal Transduction
  • Tumor Necrosis Factor-alpha / metabolism*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Atsttrin fusion protein
  • GRN protein, human
  • Granulins
  • Grn protein, mouse
  • Intercellular Signaling Peptides and Proteins
  • Ligands
  • Progranulins
  • Receptors, Tumor Necrosis Factor, Type I
  • Receptors, Tumor Necrosis Factor, Type II
  • Recombinant Fusion Proteins
  • Tumor Necrosis Factor-alpha