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Biochem Biophys Res Commun. 2011 May 6;408(2):318-21. doi: 10.1016/j.bbrc.2011.04.030. Epub 2011 Apr 12.

The 712A/G polymorphism of Brain-derived neurotrophic factor is associated with Parkinson's disease but not Major Depressive Disorder in a Chinese Han population.

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  • 1Department of Medical Psychology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu Province 210029, PR China.



Overlaps in clinical, pathological and molecular characteristics of Parkinson's disease (PD) and Major Depressive Disorder (MD-D) have promoted association studies in search of common genetic risk factors that may predispose or modify this spectrum of disorders. Experimental and clinical data suggest that genetic variations in Brain-derived neurotrophic factor (BDNF) gene may increase the risk for PD and MD-D.


Two hundred and sixty-six PD, 83 MD-D and 400 controls were recruited for this study, assessed using a battery of neuropsychological tests, and genotyped for 11757C/G, 712A/G, 196A/G, and 270C/T in BDNF gene.


712A/G was associated with 2.50-fold time risk of PD. By combining genotypes AG/AA with 712 GG genotype as reference (OR=1) in stratification analysis, AG/AA genotypes were associated with PD (OR=2.94, 95% CI=1.88-4.61). Accordingly, the A allele was significantly overrepresented in PD compared with the G allele (OR=3.16, 95% CI=2.08-4.81). This distribution in females and males were similar.


Our results suggested a novel association between BDNF 712A/G AG/AA genotypes and PD in a Chinese Han population.

Copyright © 2011 Elsevier Inc. All rights reserved.

[PubMed - indexed for MEDLINE]
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