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Biochem Biophys Res Commun. 2011 May 6;408(2):318-21. doi: 10.1016/j.bbrc.2011.04.030. Epub 2011 Apr 12.

The 712A/G polymorphism of Brain-derived neurotrophic factor is associated with Parkinson's disease but not Major Depressive Disorder in a Chinese Han population.

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  • 1Department of Medical Psychology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu Province 210029, PR China.

Abstract

BACKGROUND:

Overlaps in clinical, pathological and molecular characteristics of Parkinson's disease (PD) and Major Depressive Disorder (MD-D) have promoted association studies in search of common genetic risk factors that may predispose or modify this spectrum of disorders. Experimental and clinical data suggest that genetic variations in Brain-derived neurotrophic factor (BDNF) gene may increase the risk for PD and MD-D.

METHODS:

Two hundred and sixty-six PD, 83 MD-D and 400 controls were recruited for this study, assessed using a battery of neuropsychological tests, and genotyped for 11757C/G, 712A/G, 196A/G, and 270C/T in BDNF gene.

RESULTS:

712A/G was associated with 2.50-fold time risk of PD. By combining genotypes AG/AA with 712 GG genotype as reference (OR=1) in stratification analysis, AG/AA genotypes were associated with PD (OR=2.94, 95% CI=1.88-4.61). Accordingly, the A allele was significantly overrepresented in PD compared with the G allele (OR=3.16, 95% CI=2.08-4.81). This distribution in females and males were similar.

CONCLUSION:

Our results suggested a novel association between BDNF 712A/G AG/AA genotypes and PD in a Chinese Han population.

Copyright © 2011 Elsevier Inc. All rights reserved.

PMID:
21510922
[PubMed - indexed for MEDLINE]
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