Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Langmuir. 2011 May 17;27(10):6528-33. doi: 10.1021/la2005612. Epub 2011 Apr 21.

Voltage-controlled metal binding on polyelectrolyte-functionalized nanopores.

Author information

  • 1Department of Biomolecular Engineering, University of California Santa Cruz, 1156 High Street, Santa Cruz, California 95064, United States.

Abstract

Most of the research in the field of nanopore-based platforms is focused on monitoring ion currents and forces as individual molecules translocate through the nanopore. Molecular gating, however, can occur when target analytes interact with receptors appended to the nanopore surface. Here we show that a solid state nanopore functionalized with polyelectrolytes can reversibly bind metal ions, resulting in a reversible, real-time signal that is concentration dependent. Functionalization of the sensor is based on electrostatic interactions, requires no covalent bond formation, and can be monitored in real time. Furthermore, we demonstrate how the applied voltage can be employed to tune the binding properties of the sensor. The sensor has wide-ranging applications and, its simplest incarnation can be used to study binding thermodynamics using purely electrical measurements with no need for labeling.

PMID:
21510657
[PubMed - indexed for MEDLINE]
PMCID:
PMC3099346
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for American Chemical Society Icon for PubMed Central
    Loading ...
    Write to the Help Desk