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J Antibiot (Tokyo). 2011 Jun;64(6):453-7. doi: 10.1038/ja.2011.26. Epub 2011 Apr 20.

Benzoxacystol, a benzoxazine-type enzyme inhibitor from the deep-sea strain Streptomyces sp. NTK 935.

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  • 1Institut für Chemie, Technische Universität Berlin, Berlin, Germany.

Abstract

Benzoxacystol, a new 1,4-benzoxazine-type metabolite, was produced by strain NTK 935, a marine member of the Streptomyces griseus 16S rRNA clade, isolated from deep-sea sediment collected from the Canary Basin. The structure of benzoxacystol was determined by mass spectrometry, NMR experiments and X-ray analysis. The compound showed an inhibitory activity against the enzyme glycogen synthase kinase 3β and a weak antiproliferative activity against mouse fibroblast cells.

PMID:
21505471
[PubMed - indexed for MEDLINE]
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