Disseminated Burkholderia gladioli infection in a lung transplant recipient with underlying hypocomplementemic urticarial vasculitis

G R Thompson 3rd; B L Wickes; M L Herrera; T C Haman; J S Lewis 2nd; J H Jorgensen

doi:10.1111/j.1399-3062.2011.00638.x

Disseminated Burkholderia gladioli infection in a lung transplant recipient with underlying hypocomplementemic urticarial vasculitis

Transpl Infect Dis. 2011 Dec;13(6):641-5. doi: 10.1111/j.1399-3062.2011.00638.x. Epub 2011 Apr 19.

Authors

G R Thompson 3rd¹, B L Wickes, M L Herrera, T C Haman, J S Lewis 2nd, J H Jorgensen

Affiliation

¹ Department of Medical Microbiology and Immunology, Division of Infectious Diseases, University of California-Davis, Davis, California 95616, USA. george.thompson@ucdmc.ucdavis.edu

PMID: 21504528
DOI: 10.1111/j.1399-3062.2011.00638.x

Abstract

Burkholderia gladioli is difficult to definitively identify within the laboratory using phenotypic testing alone. We describe a case of recurrent B. gladioli infection in a lung transplant recipient with underlying hypocomplementemic urticarial vasculitis syndrome, discuss the difficulties encountered with laboratory identification, provide a review of the methodology required for definitive identification, and discuss potential pathophysiologic mechanisms in this patient responsible for the difficulty in treatment.

Publication types

Case Reports
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Burkholderia Infections / complications
Burkholderia Infections / diagnosis*
Burkholderia gladioli / isolation & purification
Complement System Proteins / immunology
Female
Humans
Lung Transplantation*
Middle Aged
Postoperative Complications*
Pulmonary Disease, Chronic Obstructive / complications
Pulmonary Disease, Chronic Obstructive / immunology
Syndrome
Systemic Vasculitis / complications
Systemic Vasculitis / immunology
Urticaria / complications
Urticaria / immunology

Substances

Complement System Proteins