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Genome Biol. 2011;12(4):R40. doi: 10.1186/gb-2011-12-4-r40. Epub 2011 Apr 18.

Comparative genome sequence analysis underscores mycoparasitism as the ancestral life style of Trichoderma.

Author information

  • 1Area Gene Technology and Applied Biochemistry, Institute of Chemical Engineering Vienna University of Technology, Getreidemarkt 9, 1060 Vienna, Austria. ckubicek@mail.zserv.tuwien.ac.at

Abstract

BACKGROUND:

Mycoparasitism, a lifestyle where one fungus is parasitic on another fungus, has special relevance when the prey is a plant pathogen, providing a strategy for biological control of pests for plant protection. Probably, the most studied biocontrol agents are species of the genus Hypocrea/Trichoderma.

RESULTS:

Here we report an analysis of the genome sequences of the two biocontrol species Trichoderma atroviride (teleomorph Hypocrea atroviridis) and Trichoderma virens (formerly Gliocladium virens, teleomorph Hypocrea virens), and a comparison with Trichoderma reesei (teleomorph Hypocrea jecorina). These three Trichoderma species display a remarkable conservation of gene order (78 to 96%), and a lack of active mobile elements probably due to repeat-induced point mutation. Several gene families are expanded in the two mycoparasitic species relative to T. reesei or other ascomycetes, and are overrepresented in non-syntenic genome regions. A phylogenetic analysis shows that T. reesei and T. virens are derived relative to T. atroviride. The mycoparasitism-specific genes thus arose in a common Trichoderma ancestor but were subsequently lost in T. reesei.

CONCLUSIONS:

The data offer a better understanding of mycoparasitism, and thus enforce the development of improved biocontrol strains for efficient and environmentally friendly protection of plants.

© 2011 Kubicek et al.; licensee BioMed Central Ltd.

PMID:
21501500
[PubMed - indexed for MEDLINE]
PMCID:
PMC3218866
Free PMC Article

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