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Genes Dev. 2011 Apr 15;25(8):795-800. doi: 10.1101/gad.2016211.

Autophagy-deficient mice develop multiple liver tumors.

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  • 1Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113-8519, Japan.


Autophagy is a major pathway for degradation of cytoplasmic proteins and organelles, and has been implicated in tumor suppression. Here, we report that mice with systemic mosaic deletion of Atg5 and liver-specific Atg7⁻/⁻ mice develop benign liver adenomas. These tumor cells originate autophagy-deficient hepatocytes and show mitochondrial swelling, p62 accumulation, and oxidative stress and genomic damage responses. The size of the Atg7⁻/⁻ liver tumors is reduced by simultaneous deletion of p62. These results suggest that autophagy is important for the suppression of spontaneous tumorigenesis through a cell-intrinsic mechanism, particularly in the liver, and that p62 accumulation contributes to tumor progression.

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