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Nucleic Acids Res. 2011 Aug;39(14):5813-25. doi: 10.1093/nar/gkr223. Epub 2011 Apr 15.

How does DNA break during chromosomal translocations?

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  • 1Department of Biochemistry, Indian Institute of Science, Bangalore 560 012, India.

Abstract

Chromosomal translocations are one of the most common types of genetic rearrangements and are molecular signatures for many types of cancers. They are considered as primary causes for cancers, especially lymphoma and leukemia. Although many translocations have been reported in the last four decades, the mechanism by which chromosomes break during a translocation remains largely unknown. In this review, we summarize recent advances made in understanding the molecular mechanism of chromosomal translocations.

PMID:
21498543
[PubMed - indexed for MEDLINE]
PMCID:
PMC3152359
Free PMC Article
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