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Int J Radiat Oncol Biol Phys. 2011 Nov 15;81(4):e325-34. doi: 10.1016/j.ijrobp.2011.02.006. Epub 2011 Apr 16.

Outcomes after intensity-modulated versus conformal radiotherapy in older men with nonmetastatic prostate cancer.

Author information

  • 1Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA. bekelman@uphs.upenn.edu

Abstract

PURPOSE:

There is little evidence comparing complications after intensity-modulated (IMRT) vs. three-dimensional conformal radiotherapy (CRT) for prostate cancer. The study objective was to test the hypothesis that IMRT, compared with CRT, is associated with a reduction in bowel, urinary, and erectile complications in elderly men with nonmetastatic prostate cancer.

METHODS AND MATERIALS:

We undertook an observational cohort study using registry and administrative claims data from the SEER-Medicare database. We identified men aged 65 years or older diagnosed with nonmetastatic prostate cancer in the United States between 2002 and 2004 who received IMRT (n = 5,845) or CRT (n = 6,753). The primary outcome was a composite measure of bowel complications. Secondary outcomes were composite measures of urinary and erectile complications. We also examined specific subsets of bowel (proctitis/hemorrhage) and urinary (cystitis/hematuria) events within the composite complication measures.

RESULTS:

IMRT was associated with reductions in composite bowel complications (24-month cumulative incidence 18.8% vs. 22.5%; hazard ratio [HR] 0.86; 95% confidence interval [CI], 0.79-0.93) and proctitis/hemorrhage (HR 0.78; 95% CI, 0.64-0.95). IMRT was not associated with rates of composite urinary complications (HR 0.93; 95% CI, 0.83-1.04) or cystitis/hematuria (HR 0.94; 95% CI, 0.83-1.07). The incidence of erectile complications involving invasive procedures was low and did not differ significantly between groups, although IMRT was associated with an increase in new diagnoses of impotence (HR 1.27, 95% CI, 1.14-1.42).

CONCLUSION:

IMRT is associated with a small reduction in composite bowel complications and proctitis/hemorrhage compared with CRT in elderly men with nonmetastatic prostate cancer.

Copyright © 2011 Elsevier Inc. All rights reserved.

PMID:
21498008
[PubMed - indexed for MEDLINE]
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