Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
    Eur J Cell Biol. 2012 Jan;91(1):78-85. doi: 10.1016/j.ejcb.2011.01.015. Epub 2011 Apr 14.

    Sensing of viral nucleic acids by RIG-I: from translocation to translation.

    Source

    Division of Clinical Pharmacology, Ludwig-Maximilian University Munich, Munich, Germany.

    Abstract

    The innate immune system is a first layer of defense against infection by pathogens. It responds to pathogens by activating host defense mechanisms via interferon and inflammatory cytokine expression. Pathogen associated molecular patterns (PAMPs) are sensed by specific pattern recognition receptors. Among those, the ATP dependent helicase related RIG-I like receptors RIG-I, MDA5 and LGP2 sense the presence of viral RNA in the cytoplasm of host cells. While the precise PAMPs and functions of MDA5 or LGP2 are still unclear, RIG-I senses predominantly viral RNA containing a 5'-triphosphate along with dsRNA regions. Here we review our current knowledge of how these PAMPs are sensed and integrated by RIG-I, and how RIG-I's innate immune function can be used in translational medical approaches.

    Copyright © 2011 Elsevier GmbH. All rights reserved.

    PMID:
    21496944
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC3155743
    Free PMC Article

    Publication Types, MeSH Terms, Substances, Grant Support

    Publication Types

    MeSH Terms

    Substances

    Grant Support

      Supplemental Content

      Icon for Elsevier Science Icon for PubMed Central

      Save items

      Recent activity

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...
      Write to the Help Desk