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J Pregnancy. 2011;2011:176973. doi: 10.1155/2011/176973. Epub 2010 Dec 23.

Renal involvement in preeclampsia: similarities to VEGF ablation therapy.

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  • 1Division of Nephrology and Hypertension, Department of Medicine, IFB-TX Hannover, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.

Abstract

Glomerular VEGF expression is critical for the maintenance and function of an intact filtration barrier. Alterations in glomerular VEGF bioavailability result in endothelial as well as in podocyte damage. Renal involvement in preeclampsia includes proteinuria, podocyturia, elevated blood pressure, edema, glomerular capillary endotheliosis, and thrombotic microangiopathy. At least the renal signs, symptoms, and other evidence can sufficiently be explained by reduced VEGF levels. The aim of this paper was to summarize our pathophysiological understanding of the renal involvement of preeclampsia and point out similarities to the renal side effects of VEGF-ablation therapy.

PMID:
21494322
[PubMed - indexed for MEDLINE]
PMCID:
PMC3066648
Free PMC Article
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