Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Am J Nephrol. 2011;33(5):407-13. doi: 10.1159/000326753. Epub 2011 Apr 15.

Urine cystatin C as a biomarker of proximal tubular function immediately after kidney transplantation.

Author information

  • 1Department of Medicine, Section of Nephrology, Yale University School of Medicine and the Clinical Epidemiology Research Center, VAMC, New Haven, CT 06516, USA.

Abstract

BACKGROUND/AIMS:

Clinical methods to predict allograft function soon after kidney transplantation are ineffective.

METHODS:

We analyzed urine cystatin C (CyC) in a prospective multicenter observational cohort study of deceased-donor kidney transplants to determine its peritransplant excretion pattern, utility for predicting delayed graft function (DGF) and association with 3-month graft function. Serial urine samples were collected for 2 days following transplant and analyzed blindly for CyC. We defined DGF as any hemodialysis in the first week after transplant, slow graft function (SGF) as a serum creatinine reduction < 70% by the first week and immediate graft function (IGF) as a reduction ≥ 70%.

RESULTS:

Of 91 recipients, 33 had DGF, 34 had SGF and 24 had IGF. Urine CyC/urine creatinine was highest in DGF for all time-points. The area under the curve (95% CI) for predicting DGF at 6 h was 0.69 (0.57-0.81) for urine CyC, 0.74 (0.62-0.86) for urine CyC/urine creatinine and 0.60 (0.45-0.75) for percent change in urine CyC. On the first postoperative day, urine CyC/urine creatinine and percent change in urine CyC were associated with 3-month graft function.

CONCLUSION:

Urine CyC on the day after transplant differs between degrees of perioperative graft function and modestly corresponds with 3-month function.

Copyright © 2011 S. Karger AG, Basel.

PMID:
21494031
[PubMed - indexed for MEDLINE]
PMCID:
PMC3100377
Free PMC Article

Images from this publication.See all images (2)Free text

Fig. 1
Fig. 2
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for S. Karger AG, Basel, Switzerland Icon for PubMed Central
    Loading ...
    Write to the Help Desk