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Genome Biol. 2011;12(4):R39. doi: 10.1186/gb-2011-12-4-r39. Epub 2011 Apr 14.

A quantitative literature-curated gold standard for kinase-substrate pairs.

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  • 1Department of Molecular Genetics, The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto,160 College Street, Toronto, M3S 3E1, Canada.

Erratum in

  • Genome Biol. 2012;13(5):417. Young, Ji-Young [corrected to Youn, Ji-Young].

Abstract

We describe the Yeast Kinase Interaction Database (KID, http://www.moseslab.csb.utoronto.ca/KID/), which contains high- and low-throughput data relevant to phosphorylation events. KID includes 6,225 low-throughput and 21,990 high-throughput interactions, from greater than 35,000 experiments. By quantitatively integrating these data, we identified 517 high-confidence kinase-substrate pairs that we consider a gold standard. We show that this gold standard can be used to assess published high-throughput datasets, suggesting that it will enable similar rigorous assessments in the future.

© 2011 Sharifpoor et al.; licensee BioMed Central Ltd.

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