Genome Biol. 2011;12(4):109. Epub 2011 Apr 11.

What does biologically meaningful mean? A perspective on gene regulatory network validation.

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Program in Gene Function and Expression, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. marian.walhout@umassmed.edu

Abstract

Gene regulatory networks (GRNs) are rapidly being delineated, but their quality and biological meaning are often questioned. Here, I argue that biological meaning is challenging to define and discuss reasons why GRN validation should be interpreted cautiously.

PMID:: 21489330; [PubMed - indexed for MEDLINE]
PMCID:: PMC3218850

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