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Vox Sang. 2011 May;100(4):418-21. doi: 10.1111/j.1423-0410.2010.01439.x. Epub 2010 Nov 23.

Menopausal status affects the susceptibility of stored RBCs to mechanical stress.

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  • 1Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.


The mechanical fragility index (MFI) is an in vitro measure of sublethal injury to RBCs. In our previous experiments, we demonstrated that an increase in sublethal injury (increasing MFI) was a component of the RBC storage lesion, and that the MFI was significantly higher amongst the RBC units from male donors compared to pre-menopausal female donors during storage. It was hypothesized that hormonal or menstrual factors contributed to this difference. In this study, we found that RBC units donated by post-menopausal women demonstrated an MFI that was significantly higher than those donated by pre-menopausal women throughout storage.

© 2010 The Author(s). Vox Sanguinis © 2010 International Society of Blood Transfusion.

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