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Muscle Nerve. 2011 Jun;43(6):878-86. doi: 10.1002/mus.21986. Epub 2011 Apr 12.

Changes in muscle T2 and tissue damage after downhill running in mdx mice.

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  • 1Department of Physical Therapy, University of Florida, Gainesville, Florida, USA.

Abstract

INTRODUCTION:

In this study we compared the effects of downhill or horizontal treadmill running on the magnetic resonance imaging (MRI) transverse relaxation time constant (T(2)) in mdx mice.

METHODS:

Mice underwent either downhill (n = 11 mdx, n = 6 controls) or horizontal running (n = 9, mdx only) on a treadmill. MRI was conducted prior to exercise, immediately afterward (∽20 minutes), and then 24 and 48 hours after exercise.

RESULTS:

A higher percentage of pixels with elevated T(2) in the lower hindlimb muscles was observed in the mdx mice compared with controls both pre-exercise (P < 0.001) and at each time-point after downhill running (P < 0.05), but not with horizontal running. The medial compartment muscles appeared to be the most susceptible to increased T(2).

CONCLUSIONS:

Downhill running provides a stimulus for inducing acute changes in muscle T(2) in mdx mice. MRI is a non-invasive approach for examining acute muscle damage and recovery in multiple muscle groups simultaneously.

Copyright © 2010 Wiley Periodicals, Inc.

PMID:
21488051
[PubMed - indexed for MEDLINE]
PMCID:
PMC3101319
Free PMC Article
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