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Expert Opin Ther Targets. 2011 Jul;15(7):873-87. doi: 10.1517/14728222.2011.577418. Epub 2011 Apr 12.

Targeting the Wnt/β-catenin signaling pathway in human cancers.

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  • 1Kyoto University Hospital, Department of Transfusion Medicine and Cell Therapy, Kyoto, Japan.

Abstract

INTRODUCTION:

The Wnt/β-catenin signaling pathway plays a pivotal role in the regulation of cell growth, cell development and the differentiation of normal stem cells. Constitutive activation of the Wnt/β-catenin signaling pathway is found in many human cancers, and is thus an attractive target for anti-cancer therapy. Specific inhibitors of this pathway have been keenly researched and developed.

AREAS COVERED:

This review discusses the potential of inhibiting the Wnt/β-catenin signaling pathway, as a therapeutic approach for cancer, along with an overview of the development of specific inhibitors.

EXPERT OPINION:

Cancer stem cells (CSCs) play a significant role in the development and recurrence of several cancers, and Wnt/β-catenin signaling is important for the proliferation of CSCs. Inhibition of Wnt/β-catenin signaling is therefore a promising treatment approach. Progress has been made in the development of screening methods to identify Wnt/β-catenin signaling inhibitors. Biomarker-based screening is an effective and promising method for the identification of compounds of interest.

PMID:
21486121
[PubMed - indexed for MEDLINE]
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