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J Biomed Nanotechnol. 2011 Feb;7(1):183-5.

Single wall carbon nanotubes block ion passage in mechano-sensitive ion channels by interacting with extracellular domain.

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  • 1Sub-DIC Bioinformatics, National Institute of Technology Raipur, Chhattisgarh 492010, India.

Abstract

Mechanosensitive ion channel transduce physical stresses to cells by the response of electro-chemicals exchange. The purpose of this study was to improve understanding of ion channel inhibition process by SWCNTs. PatchDock and FireDock results suggest that the SWCNTs interact with the extracellular domain of the ion channels. SWCNTs can be considered as the new class of ion channel inhibitors.

PMID:
21485862
[PubMed - indexed for MEDLINE]
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