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Cancer Cell. 2011 Apr 12;19(4):441-55. doi: 10.1016/j.ccr.2011.03.002.

Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression.

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  • 1Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

Abstract

Chronic pancreatitis is a well-known risk factor for pancreatic ductal adenocarcinoma (PDA) development in humans, and inflammation promotes PDA initiation and progression in mouse models of the disease. However, the mechanistic link between inflammatory damage and PDA initiation is unclear. Using a Kras-driven mouse model of PDA, we establish that the inflammatory mediator Stat3 is a critical component of spontaneous and pancreatitis-accelerated PDA precursor formation and supports cell proliferation, metaplasia-associated inflammation, and MMP7 expression during neoplastic development. Furthermore, we show that Stat3 signaling enforces MMP7 expression in PDA cells and that MMP7 deletion limits tumor size and metastasis in mice. Finally, we demonstrate that serum MMP7 level in human patients with PDA correlated with metastatic disease and survival.

Copyright © 2011 Elsevier Inc. All rights reserved.

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PMID:
21481787
[PubMed - indexed for MEDLINE]
PMCID:
PMC3075548
Free PMC Article
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