Cell Prolif. 2011 Apr;44 Suppl 1:60-9. doi: 10.1111/j.1365-2184.2010.00729.x.

The umbilical cord: a rich and ethical stem cell source to advance regenerative medicine.

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CTI-LYON, Cell Therapy Research Institute, Parc Technologique de Lyon St Priest, France.

Abstract

Science and medicine place a lot of hope in the development of stem cell research and regenerative medicine. This review will define the concept of regenerative medicine and focus on an abundant stem cell source - neonatal tissues such as the umbilical cord. Umbilical cord blood has been used clinically for over 20 years as a cell source for haematopoietic stem cell transplantation. Beyond this, cord blood and umbilical cord-derived stem cells have demonstrated potential for pluripotent lineage differentiation (liver, pancreatic, neural tissues and more) in vitro and in vivo. This promising research has opened up a new era for utilization of neonatal stem cells, now used beyond haematology in clinical trials for autoimmune disorders, cerebral palsy or type I diabetes.

PMID:: 21481046; [PubMed - indexed for MEDLINE]

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Cited by 1 PubMed Central article

Prioritization of biomarker targets in human umbilical cord blood: identification of proteins in infant blood serving as validated biomarkers in adults. [Environ Health Perspect. 2012]
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