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Nanomedicine. 2011 Oct;7(5):521-40. doi: 10.1016/j.nano.2011.03.008. Epub 2011 Apr 6.

Nanotechnologies for Alzheimer's disease: diagnosis, therapy, and safety issues.

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  • 1Laboratoire de Physico-Chimie, Pharmacotechnie et Biopharmacie, Univ Paris-Sud, Faculté de Pharmacie, Châtenay-Malabry, France.

Abstract

Alzheimer's disease (AD) represents the most common form of dementia worldwide, affecting more than 35 million people. Advances in nanotechnology are beginning to exert a significant impact in neurology. These approaches, which are often based on the design and engineering of a plethora of nanoparticulate entities with high specificity for brain capillary endothelial cells, are currently being applied to early AD diagnosis and treatment. In addition, nanoparticles (NPs) with high affinity for the circulating amyloid-β (Aβ) forms may induce "sink effect" and improve the AD condition. There are also developments in relation to in vitro diagnostics for AD, including ultrasensitive NP-based bio-barcodes, immunosensors, as well as scanning tunneling microscopy procedures capable of detecting Aβ(1-40) and Aβ(1-42). However, there are concerns regarding the initiation of possible NP-mediated adverse events in AD, thus demanding the use of precisely assembled nanoconstructs from biocompatible materials. Key advances and safety issues are reviewed and discussed.

Copyright © 2011 Elsevier Inc. All rights reserved.

PMID:
21477665
[PubMed - indexed for MEDLINE]
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