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Prev Chronic Dis. 2011 May;8(3):A64. Epub 2011 Apr 15.

Identifying metabolic syndrome in African American children using fasting HOMA-IR in place of glucose.

Author information

  • 1Department of Nutritional Sciences and Toxicology, 212 Morgan Hall, University of California at Berkeley, Berkeley, CA 94720-3104, USA. sushma@berkeley.edu

Abstract

INTRODUCTION:

Metabolic syndrome (MetS) is increasing among young people. We compared the use of homeostasis model assessment of insulin resistance (HOMA-IR) with the use of fasting blood glucose to identify MetS in African American children.

METHODS:

We performed a cross-sectional analysis of data from a sample of 105 children (45 boys, 60 girls) aged 9 to 13 years with body mass indexes at or above the 85th percentile for age and sex. Waist circumference, blood pressure, and fasting levels of blood glucose, insulin, triglycerides, and high-density lipoprotein cholesterol were measured.

RESULTS:

We found that HOMA-IR is a stronger indicator of MetS in children than blood glucose. Using HOMA-IR as 1 of the 5 components, we found a 38% prevalence of MetS in this sample of African American children and the proportion of false negatives decreased from 94% with blood glucose alone to 13% with HOMA-IR. The prevalence of MetS was higher in obese than overweight children and higher among girls than boys.

CONCLUSION:

Using HOMA-IR was preferred to fasting blood glucose because insulin resistance was more significantly interrelated with the other 4 MetS components.

PMID:
21477504
[PubMed - indexed for MEDLINE]
PMCID:
PMC3103569
Free PMC Article
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